Document Details

Document Type : Article In Journal 
Document Title :
IQGAP1 in podosomes/invadosomes is involved in the progression of glioblastoma multiforme depending on the tumor status
IQGAP1 in podosomes/invadosomes is involved in the progression of glioblastoma multiforme depending on the tumor status
 
Document Language : English 
Abstract : Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signaling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumors, suggesting a role for this protein in cell proliferation, transformation and invasion. IQGAP1 has been identified as a marker of amplifying cancer cells in GBMs. To determine the involvement of IQGAP1 in the onco-biology of GBM, we performed immunohistochemical confocal microscopic analysis of the IQGAP1 protein in human GBM tissue samples using cell type-specific markers. IQGAP1 immunostaining and subcellular localization was heterogeneous; the protein was located in the plasma membrane and, at variable levels, in nucleus and/or cytosol. Moreover, IQGAP1 positive staining was found in podosome/invadopodia-like structures. IQGAP1+ staining was observed in neurons (Map2+ cells), in cancer stem cells (CSC; nestin+) and in several macrophages (CD31+ or Iba1+). Our results indicate that the IQGAP1 protein is involved in normal cell physiology as well as oncologic processes. 
ISSN : 103-390 
Journal Name : International journal of molecular sciences 
Volume : 18 
Issue Number : 1 
Publishing Year : 1438 AH
2017 AD 
Article Type : Article 
Added Date : Sunday, May 28, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Rotoli DeborahDeborah, Rotoli InvestigatorDoctorate 
Pérez-Rodríguez Natalia DoloresNatalia Dolores, Pérez-Rodríguez ResearcherDoctorate 
Morales ManuelManuel, Morales ResearcherDoctorate 
Maeso María del CarmenMaría del Carmen, Maeso ResearcherDoctorate 
Ávila JulioJulio, Ávila ResearcherDoctorate 
Mobasheri AliAli, Mobasheri ResearcherDoctorate 

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